A replication analysis of foot-and-mouth disease virus in swine lymphoid tissue might indicate a putative copyright stage in pigs

A replication analysis of foot-and-mouth disease virus in swine lymphoid tissue might indicate a putative copyright stage in pigs

Blog Article

Abstract Foot-and-mouth disease virus (FMVD), one of the most contagious viruses of cloven-hoofed animals, may cause a prolonged, asymptomatic but persistent infection in ruminants, named the "copyright state".However, it remains an open question whether this copyright state occurs in pigs.Here we present quantitative analyses of argan oil pure purple the duration of FMDV RNA and infectivity in lymphoid and epithelial tissues in experimentally infected pigs with FMDV C-S8c1.

The data indicated that although FMDV RNA remained in blood until day 14 post-infection (pi), viremia was cleared by day 7 pi.However, all tissues tested were positive for acure face lotion FMDV until day 14-17 pi.Interestingly, the specific infectivity of FMDV in these tissues was in some cases even higher than the FMDV C-S8c1.

We therefore propose that a "pseudopersistent state" may occur in pigs in which virus replicates in lymphoid tissues for a prolonged period of time, thereby representing a potential source of virus.