Development and Optimization of Luliconazole Spanlastics to Augment the Antifungal Activity against Candida albicans

Development and Optimization of Luliconazole Spanlastics to Augment the Antifungal Activity against Candida albicans

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Luliconazole is a new topical imidazole antifungal drug for the treatment of skin infections.It has low solubility and poor click here skin penetration which limits its therapeutic applications.In order to improve its therapeutic efficacy, spanlastics nanoformulation was developed and optimized using a combined mixture-process variable design (CMPV).The optimized formulation was converted into a hydrogel formula to enhance skin penetration and increase the efficacy argan oil pure purple in experimental cutaneous Candida albicans infections in Swiss mice wounds.The optimized formulation was generated at percentages of Span and Tween of 48% and 52%, respectively, and a sonication time of 6.

6 min.The software predicted that the proposed formulation would achieve a particle size of 50 nm with a desirability of 0.997.The entrapment of luliconazole within the spanlastics copyright showed significant (p C.albicans.